Biliary Tract Malignancy
Clinical Overview and Novel Detection Method
Related Video
For information on specimen collection and processing, see Biliary Tract Malignancy by FISH Testing.
Clinical Insight
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For questions regarding the management or treatment of a patient with this condition, contact Dr. Gores (Monday-Friday) at 507-284-6488.
Impact of Disease Prevalence on Positive Predictive Value (PPV)
September 2011
Before I review several case series utilizing FISH studies for the diagnosis of pancreatobiliary strictures, I would like to emphasize the impact of disease prevalence on positive predictive value. The positive predictive value is highly dependent upon disease prevalence of the population studied. In the validation of FISH studies for the diagnosis of biliary and pancreatic malignancies, the disease prevalence was about 45%. You can see that as the disease prevalence drops, the positive predictive value decreases concomitantly. Therefore, it is difficult to extrapolate these studies performed in a diagnostic setting where the suspicion of cancer is high, to those performed in a surveillance setting where the disease prevalence is quite low.
Impact of Disease Prevalence on PPV |
Jump to section:
- Introduction
- Disclosures
- Pancreatobiliary Strictures (PBS)
- Primary Sclerosing Cholangitis (PSC)
- Pancreatobiliary Strictures (PBS)
- Bile Duct Brushings
- Current Clinical Practice
- Factors That Influence Sensitivity Of Cytology Specimens
- Routine Cytology
- Cancer Is A Genetic Disorder That Results From Mutations
- Detecting Tumor Cells in Cytology Specimens Using FISH
- Types of FISH Probes
- FISH
- Sensitivity and Specificity of Various Tests for Detection of Pancreatobiliary Strictures Malignancy
- What Do We Do With These Data?
- Bile Duct Pathology Calculator
- Representative Test Report Using Bile Duct Calculator
- Bile Duct Calculator
- Impact of Disease Prevalence on Positive Predictive Value (PPV)
- Case 1
- Case 1 Cytologic Findings
- Case 1
- Case 1 Test Report Using Bile Duct Calculator
- Case 1
- Case 1
- Case 2
- Case 2 Cytologic Findings
- Case 2
- Case 2: Test Report Using Bile Duct Calculator
- Case 2
- Case 2
- Case 3
- Case 3 Cytologic Findings
- Case 3
- Case 3
- Case 3: Test Report Using Bile Duct Calculator
- Case 3
- Case 3
- Summary
- Summary
- Results
- Questions?
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