Mobile Site ›

Biliary Tract Malignancy

Clinical Overview and Novel Detection Method



Related Video

For information on specimen collection and processing, see Biliary Tract Malignancy by FISH Testing.

Contact Dr. Gores

For questions regarding the management or treatment of a patient with this condition, contact Dr. Gores (Monday-Friday) at 507-284-6488.

Sensitivity and Specificity of Various Tests for Detection of Pancreatobiliary Strictures Malignancy

Slide 14

September 2011

As I mentioned in the previous slide, our lab has clinically validated the FISH probe set that we use for detecting pancreatobiliary malignancy. We did this by determining the clinical sensitivity and specificity of the assay in a large cohort of patients that were being evaluated for pancreatobiliary malignancy. We also simultaneously determined the clinical performance characteristics of conventional cytology and DIA for the detection of pancreatobiliary malignancy. On the left, this figure shows that if only positive cytology diagnoses were considered consistent with malignancy that cytology had a sensitivity of about 20% and a specificity of 100%. If both positive and suspicious cytology interpretations were considered consistent with malignancy then the sensitivity of cytology was about 38% and its specificity was about 97%. If positive, suspicious and atypical cytology interpretations were all considered consistent with malignancy then the sensitivity of cytology increased to about 50% but the specificity dropped to about 85%. We no longer use DIA so I will not talk about that. But this slide also shows that if only polysomic FISH diagnoses were considered consistent with malignancy that the sensitivity of FISH was about 42% with a specificity close to 100%. If both polysomic and trisomic FISH findings were considered consistent with malignancy the sensitivity jumped to 62% but the specificity dropped to about 79%. This further demonstrates the lack of specificity that trisomy has for the presence of malignancy.

Sensitivity and Specificity of Various Tests

 


Jump to section:


Key