Biliary Tract Malignancy

Primary Sclerosing Cholangitis (PSC)

September 2011

However, primary sclerosing cholangitis, abbreviated as PSC in this slide is a relatively common hepatobiliary disorder. It increases the risk of cholangiocarcinoma. This is a chronic inflammatory disorder involving the intra and extra hepatic bile ducts. It leads to biliary tract and hepatic fibrosis, biliary tract strictures, cholestasis, and cirrhosis.  PSC patients have a high risk of developing cholangiocarcinoma over their life time. Their lifetime risk is approximately 10% which is a 1000 fold greater risk than the general population. Most PSC patients are carefully followed for this potential complication by their hepatologist or gastroenterologist. If the cancer is found early, liver transplantation represents a chance for cure.

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Primary Sclerosing Cholangitis (PSC)

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Jump to section:

• Introduction
• Disclosures
• Pancreatobiliary Strictures (PBS)
• Primary Sclerosing Cholangitis (PSC)
• Pancreatobiliary Strictures (PBS)
• Bile Duct Brushings
• Current Clinical Practice
• Factors That Influence Sensitivity Of Cytology Specimens
• Routine Cytology
• Cancer Is A Genetic Disorder That Results From Mutations
• Detecting Tumor Cells in Cytology Specimens Using FISH
• Types of FISH Probes
• FISH
• Sensitivity and Specificity of Various Tests for Detection of Pancreatobiliary Strictures Malignancy
• What Do We Do With These Data?
• Bile Duct Pathology Calculator
• Representative Test Report Using Bile Duct Calculator
• Bile Duct Calculator
• Impact of Disease Prevalence on Positive Predictive Value (PPV)
• Case 1
• Case 1 Cytologic Findings
• Case 1
• Case 1 Test Report Using Bile Duct Calculator
• Case 1
• Case 1
• Case 2
• Case 2 Cytologic Findings
• Case 2
• Case 2: Test Report Using Bile Duct Calculator
• Case 2
• Case 2
• Case 3
• Case 3 Cytologic Findings
• Case 3
• Case 3
• Case 3: Test Report Using Bile Duct Calculator
• Case 3
• Case 3
• Summary
• Summary
• Results
• Questions?